Health Minister Mam Bunheng says the 25-year-old woman, who was nine months pregnant, went to a Phnom Penh hospital several days ago with flu-like symptoms and tested positive for swine flu.
He said doctors performed a cesarean section and the baby was born healthy, but the woman died Tuesday.
Cambodia's second swine-flu related death, a 47-year-old man, occurred Monday at the same hospital, the minister said.
The World Health Organization reports more than 340,000 confirmed cases of H1N1 worldwide, and more than 4,100 deaths. Many countries have stopped counting individual cases.
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